Spider-Man faces off with Schultz who has stolen Oscorp gear called the Seismic Harness Construction Resource and taken the name 'The Shocker.' Spider-Man defeats the Shocker who reveals that the gangs (examples being the Russian Mobsters, Hammerhead's crew, and Mister Negative's men) are all in fear of the 'Carnage Killer' and are at war.

After activating the cooling systems for the core at Oscorp Tower, Spider-Man works to break up the fights between Shultz' gang and the Russian criminals. Spider-Man defeats the criminals and frees the hostages. After fighting the Russian criminals and Shultz' gang, Spider-Man finds the Russian Mobsters threatening an Oscorp Industries electrical engineer named Max Dillon for information on where the Oscorp weapons are being held. He also learns that Shultz' gang and the Russian Mobsters have broken into Oscorp Tower. Peter goes home to see Aunt May and hears from the news that Carradine was murdered by a man the police call 'The Carnage Killer' as Whitney Chang reports on it. A symbol on the wall reads 'CK' in blood as Spider-Man calls 911 to report a dead body. After Spider-Man chases Carradine's car to an alleyway, he finds Carradine murdered and buried under a pile of trash. Stan considers the incident as 'water under the bridge.' Spider-Man eventually finds Carradine making a deal with some gang members in the alley behind Nuno's Bar, though Carradine escapes when Spider-Man webs one of Carradine's clients while taking a female civilian hostage. Peter Parker later heads to the comic store to check up on Stan where he apologizes for what happened to his apartment. On the way, Spider-Man stops some car thieves and rescues a man named Stan from a burning building. He tells Spider-Man that the Uncle Ben's killer is named Dennis Carradine and that he obtains weapons for clients.ДЄfter Shultz escapes, Spider-Man decides to track down Carradine. Shultz reveals he was obtaining weapons to fight Russian Mobsters in the gang war.

Shultz tries to kill Spider-Man, but is unsuccessful, and is quickly subdued. After Spider-Man stops the gang fight, and webs up the weapon crates he confronts Schultz. Spider-Man arrives at the location of Schultz, whose thugs are battling with Russian criminals, over weapons. One of the street thugs tells him that the man works for Herman Schultz, an illegal weapons smuggler.

After subduing the street thugs, he questions them regarding the criminal who shot Uncle Ben. His cover is blown by a falling obstacle and the appearance of Black Cat. Spider-Man investigates a group of street thugs hoping that one of the criminals is the one that killed Uncle Ben. Two years later, Peter has become the superhero known as Spider-Man and is still searching for the criminal that shot Uncle Ben. Peter ignores him stating 'Not my problem.' Minutes later, Uncle Ben is shot by the escaping thief and dies with Peter watching on. The store clerk rushes by, tells Peter he has been robbed, and asks for help chasing the criminal. The game begins with Peter Parker walking out of a convenience store, set two years in the past.

Amazing spider man 2 game